Vallecano are on a three-game winning run in the league, which includes the two memorable results against Sevilla and Real Madrid.
Despite having 59% possession on Sunday, the Red Devils could only manage eight shots in total and just three were on target.
Aston Villa are placed 13th in the table and have 15 points from 14 matches. They will now hope to put together a good run of form under Emery.
Man United are sitting fifth in the table and have 23 points from 13 games. Meanwhile, Aston Villa have jumped to the 13th spot and have 15 points from 14 matches.
Chelsea are not only winless in their last four league games but have also lost their last two matches. They have 21 points from 13 games to sit seventh in the table.
Both these sides have played each other a few times in this competition history and Nottingham Forest have a better record in EFL Cup against Spurs.
Sitting seventh in the Premier League table, Chelsea have 21 points from 13 games. They have gone winless in their last four league games.
Spurs are heading into this contest on the back of a 2-1 defeat at Liverpool. That loss made it their third defeat in four league games.
Birmingham are in the middle of a decent run of form and are already defying expectations in the Championship.
Stepping away from the league action for this mid-week might help Brentford in getting their A-game back on track.