Popyrin has a career-high ATP singles ranking of No. 59 achieved on 8 November 2021. He also has a career-high ATP doubles ranking of No. 247 achieved in July 2019. He turned professional in 2017 and has won 1 singles title on the ATP Tour.
Popyrin was born in Sydney, Australia to Russian parents. He began playing tennis at the Kim Warwick Tennis Academy in Hornsby at the age of four and was in attendance for the historic 2008 Australian Open third round match between Lleyton Hewitt and Marcos Baghdatis. At the age of 8, Popyrin relocated to Dubai for two years due to his father's work commitments before moving to Alicante, Spain where fellow Australian Alex de Minaur was his neighbour. Popyrin also spends time training in Nice, France, Marbella, Spain and Dubai. He has trained at the Mouratoglou Academy since April 2017.
In 2011, Popyrin won the Australian u12s Grasscourt Championships and, with Chase Ferguson, won the u12s National Claycourt Doubles Championships. In the same year he competed in the Tennis Europe u12 circuit, winning the Stork International 12 & Under in Oetwil Am See (SUI), Torneo U12 - Porto San Giorgio in Porto San Giorgio (ITA), Torneo Citta Di Padova in Padova (ITA). Popyrin lost in Semifinal at Eddie Herr International Junior Tennis Championships - IMG / Bollettieri Sports Academy Bradenton, FL (USA), Passagespoirs Le Passage (FRA), as well as Final of Campionati Internazionali BNL d'Italia U12 - Circolo Canottieri in Roma (ITA).
Popyrin received a third wildcard into the main draw of the 2021 Australian Open similar to every year since 2018, with the exception of the 2020 Australian Open where he entered the main draw as direct entry. In the first round he defeated 13 seed David Goffin after saving four match points 3–6, 6–4, 6–7(4–7), 7–6(8–6), 6–3 in 3 hours 43 minutes. He then lost in the second round to Lloyd Harris.
In February, Popyrin entered the Singapore Open and defeated Marin Čilić in the semifinal and Alexander Bublik in the final to win his first ATP title and achieved a career high singles ranking of 82.
Australian Open – 3R (2020, 2022)
French Open – 1R (2021)
Wimbledon – 2R (2021)
US Open – 1R (2020)
