England have scored 131 runs so far with eight wickets in hand, after being handed a target of 237 runs.
R Ashwin's exclusion from the Indian side could hurt Virat Kohli and team in the Oval Test against England.
Rishabh Pant registered his first half-century of the series while Shardul Thakur scored his second in the match to take India to a huge score.
Pant made his first half-century of the series as he scored 50 off 106 deliveries while Shardul scored 60 off just 72 balls.
With the exception of Virat Kohli and Shardul Thakur, no Indian batsman scored more than 20 runs in their first innings.
Team India skipper Virat Kohli has backed wicket-keeper batsman Rishabh Pant to continue his swashbuckling style of batting.
Kohli said that they would continue playing a 4-1 seam-spin combination in the match unless conditions at Lords forced them otherwise.
With India preparing to face England in the first Test of the five-match series, skipper Virat Kohli is confident in his team's preparation.
India on Tuesday announced their final 15-man squad for the World Test Championship final set to take place on Friday (18 June).