Villarreal are aiming to upset the favourites in their first major final whereas Manchester United are looking to win their first trophy under Ole Gunnar Solskjaer.
Anthony Martial and Phil Jones are not part of the travelling 26-man team to Gdansk, while there's no clarity on Harry Maguire's availability.
Wednesday will see Manchester United in their very first cup final in the Solskjaer era and the Norwegian will need all the help he can get.
The United skipper said Pep Guardiola even spoke with him as both Manchester clubs were interested in the defender during his time at Leicester City.
Solskjaer will be looking to win his first trophy as Manchester United head coach when they take on Villarreal in the Europa League final on May 26.
Unai Emery is looking for his fourth Europa League win as a coach as his Villarreal side take on Manchester United in the final on May 26.
The former English international has urged United to sign a centre-back to help them fight for the Premier League and Champions League titles.
If Maguire misses the final, it will be a big blow to the club as the defender has always been ever-present in the Premier League.
Solskjaer feels the team needs two or three players to challenge for major honours next season.
Manchester United throw away a first-half lead to draw 1-1 against Fulham at Old Trafford in the Premier League.