The pulsating clash will be a repeat of last season’s semifinal when Thomas Tuchel’s side outsmarted Real Madrid 3-1 on aggregate to reach the final.
Jurgen Klopp is well aware of the difficult challenge lying ahead of them when they travel to Emirates Stadium to face Mikel Arteta’s Gunners.
Manchester City were held to a 0-0 draw by Crystal Palace in the Premier League fixture at Selhurst Park Stadium on Monday.
Jurgen Klopp’s side will head into the last-16 second leg tie against Inter Milan on the back of a 2-0 lead which they secured in the first leg in Italy.
De Bruyne believes that this will be another exciting title race, as he feels it is a “privilege” to be a part of it.
In what was expected to be a pulsating Premier League rivalry clash, Manchester City ran away with it as comfortable winners.
United skipper did not hold back his words, claiming that the result is "disappointing" and the squad is "devastated" with the demoralising defeat.
The Pep-Guardiola managed side moved six points clear of Liverpool FC to consolidate their top spot in the Premier League.
Goals from Reece James, Christian Pulisic and a Kai Havertz double helped the Blues secure all three points.
This will be interim manager Ralf Rangnick’s most difficult challenge after taking charge of the club at the end of last year.