Sitting at the third spot in the Premier League table, Liverpool will be hoping to stay in the title race ahead of a busy run of games.
The Reds claimed victory in the 239th Merseyside derby thanks to Mohamed Salah's double and goals from Jordan Henderson and Diogo Jota.
The Liverpool manager accepts the special feeling around a derby but insists that the Reds will approach it like a ‘normal game'.
After a debut 2020-21 season at Liverpool that was afflicted by injuries and COVID-19, Tsimikas has gained more regular opportunities in the team this term.
The Reds face their third match in the space of a week when Southampton visit Anfield on Saturday in the Premier League.
The Brazilian goalkeeper wore the armband for Wednesday night’s Champions League victory over FC Porto at Anfield.
The Reds made it five wins from five in Group B after second-half goals from Thiago Alcantara and Mohamed Salah against Porto at Anfield.
Matchday five sees Liverpool host Porto at Anfield, with the top spot in Group B already secured thanks to four victories in the opening four matches.
The midfielder was restricted to just 30 appearances in all competitions during his first season with the Reds after signing from Bayern Munich.