The Pistons, who beat the Boston Celtics just before the All-Star break and had won six of their last nine games heading into the contest.
Kyrie Irving shot a supremely efficient 78.9 percent from the field, and 75 percent from three-point territory.
Luka Doncic went 9 of 21 and looked significantly less sharp than in most previous games during his monthlong scoring tear.
Barnes scores first 11 shots, as the Raptors thrash the Nets 133-97 in Brooklyn.
Markelle Fultz played 16 minutes off the bench for Orlando and tallied 10 points, six assists and two rebounds.
The Lakers are currently the ninth seed and find themselves only 2 1/2 games ahead of Portland, who has the same record as New Orleans.
Kyrie Irving was playing just his 15th game of the season. He still can't play in home games because of New York City's vaccine requirement.
Memphis Grizzlies beat Chicago Bulls thanks to a franchise-record 46 points from Ja Morant.
Murray had 31 points, 14 rebounds and 13 assists and the San Antonio Spurs outlasted the Washington Wizards 157-153.
The Boston Celtics defeated the Brooklyn Nets 129-106 thanks to a game-high 30 points by Jayson Tatum.