Djokovic's last competition was the Laver Cup which saw him play a couple of matches and come out with a 50-50 record.
Schwartzman is seeded third in the ATP 250 competition and will be looking to live up to expectations after a tough few tournaments in the recent past.
Maxime Cressy and Sebastian Korda will take on each other in the second round of the 2022 ATP Tel Aviv Open September 28.
Tomas Martin Etcheverry and Roman Safiullin will take on each other in the second round of the 2022 ATP Tel Aviv Open September 28.
Tallon Griekspoor and Vasek Pospisil will take on each other in the round of 32 of the 2022 ATP Tel Aviv Open on Tuesday, September 27.
The Dutchman recorded an impressive 6-2, 6-3 win over Sousa to advance to the round if 16 where he will face Liam Broady.
Thiem got off to a good start at the ATP 250 competition as he beat a spirited Laslo Djere 5-7, 7-6(3), 6-4 in the first round.
Novak Djokovic is the standout attraction in the field. He has been off the tour since winning his 21st Major title at Wimbledon.