The German tennis player will face the Swiss maestro in an intriguing third-round clash on Saturday.
With five years having passed, let us look back at what is a momentous achievement by Novak Djokovic - completing the career Grand Slam.
Rafael Nadal notched up his 17th straight win against Richard Gasquet as he entered the third round of the French Open with a straight sets win.
The Serbian struck 31 winners to beat Cuevas in straight sets and will play Lithuania's Ricardas Berankis next in Paris.
Novak Djokovic began his French Open 2021 in dominant fashion, registering a straight sets 6-2, 6-4, 6-2 win over Tennys Sandgren.
Roger Federer was playing his first match at the French Open since 2015 and he won in the first round.
The Serb will be aiming to put a halt to Nadal’s dominance and win his second major on clay after his triumph in 2016.
The Spaniard will be in the same half of the Roland Garros draw as his rivals Novak Djokovic and Roger Federer.
The Serbian needed three sets to defeat qualifier Andrej Martin at the Belgrade Open on Friday.
On the back of his thumping victory at Belgrade Open, the Serbian has the fifth most Open Era wins list.