The second seed needed four sets to defeat the Aussie 7-6, 6-4, 4-6, 6-2 after two hours and 58 minutes at Melbourne Park.
Kyrgios returned to the combustible John Cain Arena on Sunday after emerging from isolation and giving rowdy fans a night to remember.
The Serb's chances of winning a record-breaking tenth title in Melbourne are in jeopardy after his visa was cancelled twice.
Two members of the big three, who have won a total of 60 Grand Slams between them, are currently in doubt for the Australian Open 2022.
The Swiss maestro is the latest big name to withdraw from the Olympics. Rafael Nadal, Nick Kyrgios and Simona Halep were the others to pull out of the Summer Games.
Daniil Medvedev through to the last-16 of Wimbledon for the first time in his career meanwhile Alexander Zverev overcame a stern challenge from Taylor Fritz to book a meeting with ...
Australian tennis player Nick Kyrgios has been enjoying a memorable tournament so far at Wimbledon. He has been catching the eye of the crowd with his impressive tennis this week. ...
Andy Murray got past Oscat Otte in a five stter to go through to the round tree on Wimbledon 2021 at centre court on Thursday.