With the French Open only a few weeks away, Tsitsipas will be looking to take his game to the next level.
The third seed had a standout week, playing consistent and aggressive tennis to win his first title since winning in Lyon last May.
The final set of the match went to a tie-break with the Bulgarian recording a 6-4, 3-6, 7-6 (7-2) win over the Pole.
The 22-year-old played with a high level of intensity, widening his groundstrokes to pull his opponent around the court.
It is the second straight time the Italian has qualified for an ATP 1000 quarter-final and he will face a stern test in second seed Alexander Zverev.
Prior to the year's first clay-court ATP Masters 1000 event, Alcaraz stated that he was not physically or mentally exhausted.
Returning to the Monte-Carlo Country Club this week, the defending champion expressed his confidence and excitement.
The competition is one of the oldest and most prestigious tennis tournaments in the world and 2022 will be the 125th year since its inception.
Thiem announced that he had tested negative for the virus and would undergo a medical examination before returning to action.
Apart from the four Grand Slams, the Monte Carlo Masters is arguably one of the most prestigious men's tennis competitions in the world today.