Daniil Medvedev has yet to win a tournament in 2022, but he appears to be determined to change that this week at the Libema Open in Hertogenbosch.
Medvedev will go up against French tennis player Adrian Mannarino and Auger-Aliassime will take on The Netherlands' Tim van Rijthoven.
Khachanov has made it through to the round of 16 with his dominant victory over Tabilo by a score-line of 6-3, 6-3.
The tournament was last conducted in 2019, following a double postponement due to the COVID-19 pandemic.