The 3-hour, 1-minute victory is the longest match of Swiatek's young career at a Grand Slam to date.
For only the second time in his career, the Russian star bounced back from a two-sets-to-love deficit under the lights at Rod Laver Arena on Wednesday.
Denis Shapovalov produced one of the biggest upsets till now at the Australian Open, beating World No.3 Alexander Zverev on Sunday.
The second seed needed four sets to defeat the Aussie 7-6, 6-4, 4-6, 6-2 after two hours and 58 minutes at Melbourne Park.
Zverev lived up to the pre-tournament predictions as one of the favourites to win the Grand Slam by producing a dominant display during the one-hour, 59-minute victory.
The German third seed is vying for his first major title at the Australian Open 2022.
Djokovic ended weeks of speculation about his participation in the 2022 Australian Open on Tuesday and landed in Melbourne on Wednesday.
The Serbian has informed that he has an "exemption permission" to play at the season-opening Grand Slam without a Covid-19 vaccination.
Craig Tiley, the chief executive of the Australian Open, thinks there is still a lot to work out before Djokovic arrives in Australia.
The Greek star, considered one of the challengers for the Grand Slam title, suffered a stunning five-set loss in the third round of the US Open.