After the third day was washed out, Pakistan began the fourth day from 188-2 and declared at 300-4 after lunch.
Misbah, who is asymptomatic, will now remain in quarantine in Jamaica for 10 days and will be allowed to return to Pakistan upon clearing subsequent Covid tests.
Pakistan are on top after the end of day 3 of the second Jamaica Test against West Indies thanks to Fawad Alam's century.
Azam, who is also the Test skipper for Pakistan, played a captain's knock as he made 75 runs off 175 deliveries. He was exceptionally supported by Alam.