Cristiano Ronaldo and Edinson Cavani scored the opening two goals, as Manchester United comfortably beat Spurs 3-0.
An incredible end to the match saw Aston Villa snatch a late winner and Bruno Fernandes miss the chance to equalise from the spot deep into injury time.
Cavani, who is in contention to be included in the squad for the Premier League meeting with Aston Villa, could soon link up with Ronaldo up front.
Cristiano Ronaldo inherits the number from Edinson Cavani, who wore the shirt last season and in the club's away win at Wolverhampton Wanderers last weekend.
Varane, who was announced in front of the fans at Old Trafford last weekend, could be in line for his debut, while Cavani could also play some part at St Mary’s.
While providing the update on the Uruguayan striker’s situation, the Manchester United manager also spoke about Amad and Eric Bailly’s availability.
Argentina beat Bolivia 4-1 to advance to the quarter-final of Copa America 2021 as Group A winners courtesy of a brace from Lionel Messi.
Uruguay beat Bolivia 2-0 at Arena Pantanal courtesy of an own goal from Jairo Quinteros and a second half strike from Edinson Cavani.
Argentina beat Uruguay 1-0 at Brasilia on Friday courtesy of Guido Rodriguez's lone goal in the 13th minute and secured three points.
Argentina and Uruguay square off in Copa America action on Saturday, in a clash between the two favorites to qualify out of group B.