Lanus will host Independiente del Valle in the second leg of the Copa Sudamericana last-16 fixture on Thursday.
Santos will host Deportivo Tachira in the second leg of the Copa Sudamericana last-16 fixture at Estadio Urbano Caldeira on Wednesday night.
Melgar will host Deportivo Cali in the second leg of the Copa Sudamericana last-16 fixture at Estadio Monumental on Wednesday night.
Olimpia will host Atletico Goianiense in the first leg of their Copa Sudamericana last-16 fixture at Estadio Defensores del Chaco on Thursday.
Universidad Catolica will host Sao Paulo in the first leg of their Copa Sudamericana last -16 fixture at Estadio San Carlos de Apoquindo on Thursday.