Valencia are sitting at the 12th spot in the table with 20 points from 17 games, while Athletic Bilbao are placed eight in the table with 26 points from 18 matches.
Atletico Madrid, who got past Levante 2-0 in the last round, won their weekend match against Valladolid 3-0.
Athletic Bilbao are winless in their last four league games and lost their last match against La Liga title holders Real Madrid 2-0 at the weekend.
Osasuna will host Sevilla in the Copa del Rey quarter-final fixture at El Sadar on Wednesday night.
Real Sociedad are sitting third in the La Liga table with 38 points from 18 games. They are on a five-match winning streak in the league.
The La Liga table toppers will undoubtedly be labelled as the favourites, however, Sociedad will be no pushover.
Barcelona will travel to Alfonso Murube Stadium to take on Spanish third tier side Ceuta in the Copa del Rey round of 16 fixture on Thursday night.
Levante will play host to Atletico Madrid in a Copa del Rey round of 16 fixture at Estadio Ciudad de Valencia on Wednesday night.
Real Madrid though will be eager to get back to winning ways quickly after losing 3-1 to Barcelona in the final of the Supercopa de Espana.
Real Betis will host Osasuna in a Copa del Rey fixture at Benito Villamarin on Wednesday night.