Jayson Tatum led Boston with 23 points and 12 rebounds. Brown scored 19 points and Schroder had 16 points and eight assists for Celtics.
Randle added 22 points for the Knicks, Quickley had 16, and Barrett 13. The Knicks didn't lead until there were just over two minutes left.
Brown is the seventh player in team history to score 50 and the fourth Celtic to reach 50 points and 10 or more rebounds in a game.
Minnesota Timberwolves were playing without all five of their regular starters due to COVID-19 health and safety protocols.
Jaylen Brown scored 34 points and the Boston Celtics beat depleted Cleveland 111-101 on Wednesday night to end the Cavaliers' winning streak.
Embiid scored 17 of his 41 points in the fourth quarter, hitting three jumpers in the final minutes and three free throws to ice it.