Musetti has been quite impressive on clay so far and his previous win came at the Monte Carlo Masters when he beat world no. 9 Felix Auger-Alliasme.
The star attractions, therefore, include the likes of young Spaniard Carlos Alcaraz, Diego Schwartzman, Casper Ruud, Cameron Norrie, and Stefanos Tsitsipas.
The 21-time Grand Slam winner will vie for his fourth title in 2022 before the French Open in Paris.
Rafael Nadal defeated Stefanos Tsitsipas 6-4, 6-7(6), 7-5 on Sunday to win the Barcelona Open for a record-extending 12th time.
Rafael Nadal becomes the first player in the Open Era to have won 450 matches on two different surfaces.
Rafael Nadal beat compatriot Pablo Carreno Busta in the second semi-final of the Barcelona Open on Saturday to book a summit clash against Stefanos Tsitsipas.
Greek tennis star Stefanos Tsitsipas booked his place in the finals of the Barcelona Open with a convincing win over Jannik Sinner in the semi-finals.
The Spaniard, who also needed three sets in his previous round, will next play Cameron Norrie in Barcelona
King of Clay, Rafael Nadal, suffered a shock quarterfinal exit against Andrey Rublev at the Monte Carlo Masters last week.
Stefanos Tsitsipas was in the form of his life last week as he did not drop a set en route to winning the Monte Carlo Masters