Hawks have been one of the league's most underachieving teams after making a surprising run to the Eastern Conference final last season.
Miami coach Erik Spoelstra said his players haven't used injuries and COVID-19 protocols as reasons they shouldn't win.
Monk scored 21 points in the first half while hitting eight of his first nine shots in his latest impressive performance for the Lakers.
Trae Young has now scored at least 25 points in 16 straight games, the league's longest such streak this season.
The loss of De'Andre is significant for a Hawks team that has had a disappointing start to the 2021-22 season.
Trae Young appeared to bump into a referee on the baseline as he turned around to head up the court after Atlanta scored a basket.
Giannis Antetokounmpo suffered a severe hyperextension of his left knee while playing against Atlanta Hawks in the Conference finals.
The Atlanta Hawks still feel like they have a lot to prove and are entering the new campaign with an underdog mindset, according to Bogdan Bogdanovic.
Rondo was a key member of the 2020 Lakers championship team, but left for a two-year, 15 million dollars deal with the Atlanta Hawks.
The Bucks officially announced Giannis hyperextended his knee, but no further details are available at this point.